An Exchange 2010 migration to Office 365 can be achieved following a number of different methods. Microsoft no longer support Exchange 2010, which means you cannot run the Exchange Hybrid Wizard to migrate to Office 365.
Exchange 2010 Upgrade to Exchange 2019
You can choose to do a series of on-premise Exchange Server upgrades, to move through the different versions. This would be a migration from Exchange 2013 to Exchange 2016, then a migration from Exchange 2016 to Exchange 2019.
Once on Exchange 2019 you could use the Exchange Hybrid migration method, and connect your up to date Exchange 2019 Organization with Office 365 for coexistence and migration.
PST Migration from Exchange 2010 to Office 365
The other option is to consider a PST migration to Office 365. All mailboxes on Exchange 2010 can be exported to PST file. The PST files can be ingested into Office 365 Exchange Online using the free AZCOPY tool from Microsoft.
There are considerations around Active Directory, mail flow, address books, AD sync to 365, coexistence. Any Exchange 2010 upgrade to reach Exchange 2019 could be done after the PST mailbox migration to Office 365.
Migrate from Exchange 2010 to Office 365 via an Email Archiving Product
The last method to consider is to use a 3rd Party email archiving solution. Then archive all Exchange 2010 email, and allow users to start with a clean mailbox in Office 365. Requires more planning, but could be done quickly over a weekend.
Conclusion | Best Method to Migrate from Exchange 2010 to Office 365
Book a free consultation to discuss which Exchange 2010 migration to Office 365 works best for your requirements. Office365migrate.com can help you migrate safely from Exchange 2010 to Office 365.